Review Article

The AESTHETICS 2023; 4(1): 1-5

Published online April 30, 2023

© Korean Association For Laser Dermatology And Trichology

A Review on “Skin Boosters”: Hyaluronic Acid, Poly-L-lactic Acid and Pol-D-lactic Acid, Polydeoxyribonucleotide, Polynucleotides, Growth Factor, and Exosome

Kyu-Ho Yi, MD, PhD1,†, Min-Soo Park, MD2,†, Yoo-Seock Ree, MD2, Hyoung Moon Kim, MD, PhD3

1Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea
2Gangnam View Best Clinic, Seoul, Korea
3Maylin Clinic (Ilsan), Goyang, Korea

Correspondence to: Hyoung Moon Kim
Maylin Clinic, Goyang 10391, Korea

Received: March 2, 2023; Accepted: March 7, 2023

This is an open access article distributed under the terms of the Creative Commons Attribution Non- Commercial License ( which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


The term “skin booster” was introduced in 2015 to describe the use of “Restylane Vital” and “Vital Light” hyaluronic acid filler products to improve skin aging and reduce wrinkles by supplying hyaluronic acid filler to the dermis. Previously, hyaluronic acid fillers were mainly used to increase skin volume. Skin boosters are a range of ingredients used to improve dermal conditions. Although Restylane Skinboosters such as “Restylane Vital” and “Vital Light” are registered trademarks, the term “skin booster” is now commonly used by the public, just as “Botox” is used for botulinum toxin produced by Allergan. The article discusses representative skin booster ingredients, but there is no clear definition of the term. The authors believe that skin boosters include various ingredients used to improve the extracellular matrix of the dermis to enhance the skin’s condition. It is important to note that products approved as cosmetics in Korea but delivered through injection to the dermal layer or below violate medical law. Therefore, caution should be exercised when selecting products. This article focuses on introducing five main ingredients that have recently become issues: hyaluronic acid, polydeoxyribonucleotide, polynucleotide, oligonucleotide, and amino acids. The article discusses provided unbiased descriptions of their clinical experiences to help readers make informed choices. In the article it is not promoted with specific products for profit, and the product evaluation is based purely on clinical experience. In conclusion, skin boosters are a range of ingredients that improve the dermal condition of the skin, and this article provides information on popular ingredients to help readers choose the right products.

Keywords: Skin booster, Hyaluronic acid filler, Botulinum neurotoxin, Poly-L-lactic acid, Pol-D-lactic acid, Polydeoxyribonucleotide, Polynucleotides, Growth factor, Exosome